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The hair takes its shape, size and direction from its:

  1. cortex

  2. cuticle

  3. medulla

  4. follicle

The correct answer is: follicle

The hair is produced and grown from hair follicles located under the skin. These follicles determine the shape, size, and direction of hair growth. The cortex, cuticle, and medulla are all layers of the hair shaft itself, but do not play a role in determining the shape, size, or direction of the hair. Therefore, option D - follicle, is the correct answer.